2011 Research Topics


In 2011, the Brain Research Foundation Seed Grant Program funded critical research in 18 areas of neuroscience. In addition to our annual seed grant program, the Foundation awarded two larger grants to distinguished investigators in 2011. Drs. Xavier Castellanos and Paul Greengard were chosen to receive $150,000 each to pursue exciting research in attention deficit hyperactivity disorder (ADHD) and Parkinson’s disease (PD) respectively. Click on each of the topics below to learn more about the studies and how they’ll contribute to the field of neuroscience.

Click here to find out about previous research topics.

Attention-deficit/hyperactivity disorder (ADHD)
F. Xavier Castellanos, M.D.
Neidich Professor of Child and Adolescent Psychiatry at 
NYU Langone Medical Center and Nathan Kline Institute  

Parkinson’s disease
Paul Greengard, Ph.D.
Vincent Astor Professor, Laboratory of Molecular and Cellular Neuroscience 
of the Comparative Bioscience Center, Rockefeller University 

Sleep Disorders and Neurodegenerative Diseases
Circadian Clocks and Neurodegeneration
2011 Seed Grant
Ravi Allada, M.D.
Department of Neurobiology and Physiology
Northwestern University

Ischemic Stroke
Could HuR, a regulator of growth factor mRNAs, improve outcome after ischemic stroke?
2011 Seed Grant
Agnieszka Ardelt, M.D., Ph.D. 
Department of Neurology
University of Chicago

Trace Amine-Associated Receptors
Analysis of Trace Amine-Associated Receptor cluster deletion mice
2011 Seed Grant
Thomas Bozza, Ph.D.
Department of Neurobiology and Physiology
Northwestern University

Neuron Development
N-cadherin regulation of the adult neural stem cell niche
2011 Seed Grant
Anjen Chenn, M.D., Ph.D.
Department of Pathology
Northwestern University

Periventricular Heterotopia (PH)
Molecular genetic analysis of Filamin functions in cerebral cortical development
2011 Seed Grant
Yuanyi Feng, M.D., Ph.D.
Department of Neurology
Northwestern University

Odor Coding in the Brain
Perceptual Coding of Natural Odors in the Human Brain
2011 Seed Grant
Jay Gottfried, M.D., Ph.D.
Department of Neurology
Northwestern University

Autism Spectrum Disorder
Is there a cerebellar component of autism? A study using the 'Chromosome 7 duplicated' (Dup) mouse model
2011 Seed Grant
Christian Hansel, Ph.D.
Department of Neurobiology
University of Chicago

Adult Brain Neurogenesis
Regulation of Neural Stem Cells by Amyloid Precursor Protein Metabolites in the Adult Brain 
2011 Seed Grant
Orly Lazarov, Ph.D.
Department of Anatomy and Cell Biology
University of Illinois at Chicago

Rett Syndrome
Cell type-specific alterations in a genetic animal model of Rett syndrome
2011 Seed Grant
Gianmaria Maccaferri, M.D., Ph.D.
Department of Physiology
Northwestern University

Brain Circuits Modulating Reward and Addiction
Habenular modulation of dopamine neurons and its relevance for cocaine addiction 
2011 Seed Grant
Michela Marinelli, Ph.D.
Department of Cellular and Molecular Pharmacology
Rosalind Franklin University

Genetic Prion Disease
Treatment of Genetic Prion Disease by Mutation-Selective RNAi 
2011 Seed Grant
James Mastrianni, M.D., Ph.D.
Department of Neurology
University of Chicago

Huntington's Disease
Effects of Mutant Huntingtin on Cytoplasmic Dynein Phosphorylation and Function 
2011 Seed Grant
Gerardo Morfini, Ph.D.
Department of Anatomy and Cell Biology
University of Illinois at Chicago

Autism Spectrum Disorder
Validation of synaptic targets in autism spectrum disorders
2011 Seed Grant
Peter Penzes, Ph.D.
Department of Physiology
Northwestern University

Sensory and Motor Development
Sensorimotor processing in the zebrafish cerebellum
2011 Seed Grant
Indira Raman, Ph.D.
Department of Neurobiology and Physiology
Northwestern University

Adolescent Alcohol Consumption - It's Effect on Risk-Preference
Effect of adolescent alcohol consumption on risk-preference and neural encoding of risky rewards
2011 Seed Grant
Jamie Roitman, Ph.D.
Department of Psychology
University of Illinois at Chicago

ALS; Lou Gehrig's Disease
Cortical mechanisms in a mouse model of amyotrophic lateral sclerosis
2011 Seed Grant
Gordon Shepherd, M.D., Ph.D.
Department of Physiology
Northwestern University

Galectins - How They Alter Brain Function
Galectin modulation of excitatory transmission 
2011 Seed Grant
Geoffrey Swanson, Ph.D.
Department of Molecular Pharmacology and Biological Chemistry
Northwestern University

Neocortical Pyramidal Neurons
Nicotinic modulation of the excitability of neocortical pyramidal neurons
2011 Seed Grant
Jack Waters, Ph.D.
Department of Physiology
Northwestern University