Aggressive Behavior

Excessive or uncontrollable aggression is a highly destructive force in society. Pathological aggression is a relatively common problem that occurs in a number of psychiatric disorders. Furthermore, genetic factors have been shown to influence the expression of aggressive behavior in both humans and animals. Dr. Dulawa’s study proposes to identify a novel mutation that modulates aggressive behavior in mice. We recently identified an inbred mouse strain, BALB/cJ, in which spontaneous mutation has resulted in a robust increase in the expression of offensive aggressive behavior; this finding provides a unique opportunity to identify a novel gene for aggressive behavior. The present proposal describes studies designed to identify the mutated gene. Ultimately, isolating a novel gene for aggression in mice will allow us to.evaluate the potential role of the same gene in human aggression. Identifying a novel gene for aggressive behavior will ultimately allow us to better understand the mechanisms underlying both normal and pathological aggression, and develop effective treatments and interventions.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…