Brain Tumors

The success of gene therapy depends on efficient gene delivery into target cells. Viral vectors, in the forms of adenoviruses, have provided one potential means for the delivery of gene therapy. However, the potency of adenoviral agents is determined directly by their capability of infecting target cells. Most adenoviruses used for gene therapy have been based .on serotype S (AdS). Unfortunately, expression of the primary receptor for AdS, or CAR, is deficient on malignant brain tumor cells. We therefore explored substituting the receptor binding domain of AdS with adenovirus serotype 3 (Ad3). Our preliminary data suggest that this chimeric virus exhibits superior potential for glioma gene therapy.
Since malignant gliomas remain one of the most devastating of human illness for which there is no cure, the development of novel therapeutic approaches is desperately needed. The creation chimeric viral vectors with enhanced potential not only for gene therapy but also oncolysis offers a powerful approach for combating these tumors and may offer a new direction in the design of gene therapy vectors for human disease.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…