Cerebral Salt Wasting

Cerebral salt Wasting leading to hyponatremia in patients with aneurysmal SAH can be a devastating entity. Its pathophysiology is not well understood yet. Establishing a causal relationship between marinobufagenin and this sodium balance disorder will help establishing an appropriate diagnostic algorhytm, predicting the CSW development and elaborating antibodies against marinobufagenin for the treatment of this disorder.
The decrease in the serum sodium level carries potentially deadly consequences. It is a common finding in patients with some kinds of intracranial hemorrhages. The mechanisms involved in the genesis of this disorder are not well understood and also a matter of debate at the present time. Dr. Goldenberg’s lab is trying to establish a link between a naturally occurring substance, marinobufagenin, and this metabolism alteration. There is experimental evidence that suggests that it is elevated in some disease states where there is an increased urinary excretion of sodium resulting in a drop of its serum levels. If they can establish this causal relationship, they will be able to understand the pathophysiology better, make the diagnosis of this disorder simpler, predict its occurrence and eventually develop a treatment for it.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
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How the nervous system constructs internal models of the external world
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Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…