Cerebral Salt Wasting

Cerebral salt Wasting leading to hyponatremia in patients with aneurysmal SAH can be a devastating entity. Its pathophysiology is not well understood yet. Establishing a causal relationship between marinobufagenin and this sodium balance disorder will help establishing an appropriate diagnostic algorhytm, predicting the CSW development and elaborating antibodies against marinobufagenin for the treatment of this disorder.
The decrease in the serum sodium level carries potentially deadly consequences. It is a common finding in patients with some kinds of intracranial hemorrhages. The mechanisms involved in the genesis of this disorder are not well understood and also a matter of debate at the present time. Dr. Goldenberg’s lab is trying to establish a link between a naturally occurring substance, marinobufagenin, and this metabolism alteration. There is experimental evidence that suggests that it is elevated in some disease states where there is an increased urinary excretion of sodium resulting in a drop of its serum levels. If they can establish this causal relationship, they will be able to understand the pathophysiology better, make the diagnosis of this disorder simpler, predict its occurrence and eventually develop a treatment for it.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…