Devic’s Disease

This study will address several questions:  1A) are the inflammatory cytokines and immune cells similar in patients with Devic’s disease vs. peripheral Sjogren’s disease; 1B) what is the identity of cytokines and immune cells that vary with clinical attacks of disease worsening in Devic’s disease; 2A) do patients with Devic’s disease have aquaporin 1, aquaporin 5, and muscurinic receptor antibodies as seen in patients with peripheral Sjogren’s disease; 2B) what is the isotype of antibodies seen in Devic’s disease that react with aquaporin 1, -5, and muscurinic receptors; 3) are T cells isolated from CSF of Devic’s patients capable of reacting with aquaporin antigens, such as aquaporin 1, 4 and 5, thus identifying possible antigens that may be stimulating an abnormal immune response in Devic’s disease.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…