Devic’s Disease

This study will address several questions:  1A) are the inflammatory cytokines and immune cells similar in patients with Devic’s disease vs. peripheral Sjogren’s disease; 1B) what is the identity of cytokines and immune cells that vary with clinical attacks of disease worsening in Devic’s disease; 2A) do patients with Devic’s disease have aquaporin 1, aquaporin 5, and muscurinic receptor antibodies as seen in patients with peripheral Sjogren’s disease; 2B) what is the isotype of antibodies seen in Devic’s disease that react with aquaporin 1, -5, and muscurinic receptors; 3) are T cells isolated from CSF of Devic’s patients capable of reacting with aquaporin antigens, such as aquaporin 1, 4 and 5, thus identifying possible antigens that may be stimulating an abnormal immune response in Devic’s disease.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…