Ischemic Optic Neuropathy

This project will use a rat model of peri-operative ischemic optic neuropathy (ION) to examine mechanisms of axonal injury and to provide important new data to understand and prevent an important clinical problem that results in visual loss.  Outcome after ischemia will be primarily studied using functional criteria (evoked response to light flashes, and antegrade transmission of tracers through the visual pathway measured using magnetic resonance imaging), by the degree of edema or demyelination in the optic nerve (by MRI), and by molecular markers of cell death in the retinal ganglion cells.  By manipulating systemic blood pressure, hemoglobin levels, and head position in rats placed for prolonged time periods in the prone position, we will examine the mechanisms of the devastating injury and begin to evaluate preventive strategies.

Ischemic optic neuropathy is a devastating injury that results in visual loss.  By gaining a better understanding of the mechanisms of this injury, we will diminish suffering and the cost of care for these patients.  In addition, we will gain insights into the mechanisms of axonal loss after ischemia.  Axonal loss occurs in other conditions such as stroke, and therefore the implications of our findings could be more widely applied.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…