Molecular mechanisms of neocortical cell type specification

The largest structure in the human brain is the cerebral cortex. The distinctive feature of the cerebral cortex is that it is organized into layers, each of which has a specific function. A key question in neuroscience is how the cells of the different cortical layersare produced in development. The Ragsdale laboratory has identified cortical cell types in a key model organism for developmental studies, the chick embryo. In the proposed research the Ragsdale laboratory will collect preliminary data in the chick embryo on the developmental mechanisms involved in generating cortical cell types. Such preliminary data is essential to compete for NIH grant support for this work.
The cerebral cortex is a major site of injury and disease in the human brain. One possible treatment for cerebral cortex damage is cell replacement, either by stimulating resident neural stem cells or by supplying stem cells from other parts of the body. To control the generation of the correct kinds of replacement cells, we need to understand how the neurons we plan to replace are generated in normal development. This is the goal of Dr. Ragsdale’s proposed research.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…