Prion Disease

There is a great urgency to better understand the manner in which prions (PrPSc) generate and propagate, as BSE (mad cow disease) is currently a major health threat abroad and the rapid spread of CWD throughout the U.S. is  a major concern here at home.  The BSe outbreak has led to the development of a TSE Advisory group to the FDA, to ensure the safety of the U.S. blood supply.   In addition, the spread of CWD HAS Led to the mandatory culling of deer and elk in several states.  Thus, understanding the mechanism and determinants of the transmissible capacity of prion disease is of great importance.  Inherent within our studies is the potential to find treatment strategies for prion disease.  Our spontaneous disease mouse models will provide insight into the genetic prion disease determinants and will eventually prove useful for the testing of potential treatments for prion disease.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…