Vision

Humans and other advanced animals are not born with a built in library of meaningful categories, such as “tables” and “chairs,” which we are preprogrammed to recognize. Instead we learn to recognize the meaning of such stimuli through experience. This ability, which is disrupted by a number of brain diseases and conditions such as Alzheimer’s disease, schizophrenia and stroke, is critical because it allows us to respond appropriately to the continuous stream of stimuli and events that we encounter in our interactions with the environment.
 
While much is known about the encoding of basic visual features (such as contrast, orientation, and motion direction) in early stages of the visual system, much less is known about how the brain learns, stores, recognizes and recalls the meaning of our sensory experiences. With his 2008 Brain Research Foundation Seed Grant, Dr. David J. Freedman conducted research to determine a more detailed understanding of the brain mechanisms of visual learning, memory and recognition.
 
A greater understanding of visual learning and categorization is important for addressing a number of brain disorders and conditions that leave patients impaired in everyday tasks that require an appropriate response to sensory information. These studies also have particular relevance for understanding and addressing learning disabilities, such as attention deficit disorder and dyslexia, which affect a substantial number of school age children and young adults. The long-term goal of Dr. Freedman’s research is to help guide the next generation of treatments for these brain-based diseases and disorders by helping to develop a detailed understanding of the brain mechanisms that underlie learning, memory and recognition.
 
Results from this study enabled Dr. Freedman to submit a proposal to the National Science Foundation (NSF). In 2010, Dr. Freedman was awarded the NSF CAREER award for junior faculty. This award is a five year grant in the amount of $950,000.
The NSF is an independent federal agency that supports all fields of fundamental science and engineering.
 
Dr. David Freedman’s 2008 BRF Seed Grant award leads to a $950,000 grant from the National Science Foundation.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…