Dissecting microglial function in neuroinflammation by mapping nitric oxide in real time in the living brain
Nitric oxide (NO), a gaseous chemical messenger, is a neuroprotective agent in the brain. It is vital to brain function, as controlled amounts are critical to triggering important signaling mechanisms. NO also causes neurodegeneration, as seen in conditions like stroke, Alzheimer’s, Parkinson’s, and dementias. We seek to spatiotemporally image NO within the living brain, using molecularly programmed DNA-based nanodevices, which would offer deep insights into mechanisms of neurodegeneration.