Neural Circuit Mechanisms in the Early Stage of Alzheimer’s Disease

2017 Seed Grant
Kei Igarashi, Ph.D.
University of California, Irvine

In Alzheimer’s disease, even a small improvement in a patient’s memory may provide them with a vast improvement in their quality of life. ln my previous studies, I discovered that neurons from two separate regions of the rat brain develop a synchronized electrical signal that may help increase long-term memory formation during learning (lgarashi et al., Nature 2014). This project will test if this synchronized brain activity is affected in an Alzheimer’s disease mouse model, and explore the possibility that healthy neuronal activity can be restored, leading to the promise of improving learning and performance in people suffering from Alzheimer’s and other memory impairments.