Understanding how psychedelics affect top-down belief propagation in the primate brain

Dr. Doris Tsao

Dr. Doris Tsao,
University of California,
Berkeley

Our research will try to understand how special substances called psychedelics can help the brain see the world differently. When people are sad or worried, their brains sometimes get “stuck” thinking the same way over and over again, like a broken record. Psychedelics seem to help the brain break out of those patterns.

We’re studying how this works by showing pictures of faces while brain activity is being carefully measured. We’ll administer psychedelics to see how the brain changes when we show ambiguous pictures that can be interpreted in multiple ways. We think that psychedelics help the brain by loosening its “old ideas” and making it more open to new information.

We hope this research will help us learn more about treating diseases like depression, anxiety, and PTSD (post-traumatic stress disorder), where people’s thoughts and feelings can get stuck in painful ways. We hope our work will lead to new, better treatments that help people feel better and more flexible in their thinking.

Other Awards

Robert Froemke Ph.D. NYU School of Medicine
The Neuroscience of Families: Social Behavior in Naturalistic Controlled Environments
Robert FroemkePh.D.NYU School of Medicine Animals can work together in groups to achieve specific aims with higher success rates than if acting alone. For communally-living and consociating species such as…
Ken Prehoda, Ph.D. University of Oregon
Brain Regeneration Dynamics Using the Transparent Fish Danionella Cerebrum
2025 Scientific Innovations AwardKen Prehoda, Ph.D.University of Oregon Regenerative medicine may one day enable us to repair brain damage caused by injury and disease. While humans and other mammals cannot…
James J DiCarlo, M.D., Ph.D., Massachusetts Institute of Technology
Using Computer Models of the Neural Mechanisms of Visual Processing to Non-Invasively Modulate Brain States
DiCarlo’s research team is exploring an innovative approach to address emotional challenges, such as anxiety and depression. Traditional treatments for these disorders can be complex and often cause unpleasant side effects,…
Eiman Azim, Ph.D., The Salk Institute for Biological Studies
Learning from Error: Defining how Cerebellar Circuits Drive Adaptation in a Changing World
The ability to move effectively through the world is one of the most important functions of the brain. However, the world and the body are constantly changing, meaning the signals…