A Modular System for Temporal and Cell-type Specific Manipulation of Neural Circuits

2019 Seed Grant
Tiffany Schmidt, Ph.D.
Northwestern University

Women’s Council Seed Grant

One major hurdle to treating diseases affecting vision is a fundamental lack of understanding of how light signals sent from the retina influence our behavior and physiology. In the proposed work, we will develop a suite of genetic tools to label, manipulate, and ablate specific subsets of retinal neurons at specific times. These tools have the potential to expand our understanding of the basic functions and wiring of the visual system in health and how this signaling goes wrong in disease. Most importantly, these tools will be made available to the wider neuroscience community where they could aid in the understanding of how specific neuronal cell types contribute to neurodegenerative diseases, neurodevelopmental disorders, and mental health issues.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…