A Modular System for Temporal and Cell-type Specific Manipulation of Neural Circuits

2019 Seed Grant
Tiffany Schmidt, Ph.D.
Northwestern University

Women’s Council Seed Grant

One major hurdle to treating diseases affecting vision is a fundamental lack of understanding of how light signals sent from the retina influence our behavior and physiology. In the proposed work, we will develop a suite of genetic tools to label, manipulate, and ablate specific subsets of retinal neurons at specific times. These tools have the potential to expand our understanding of the basic functions and wiring of the visual system in health and how this signaling goes wrong in disease. Most importantly, these tools will be made available to the wider neuroscience community where they could aid in the understanding of how specific neuronal cell types contribute to neurodegenerative diseases, neurodevelopmental disorders, and mental health issues.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…