Aberrant Synaptic Organization in Tremor Disorders

2018 Seed Grant
Sheng-Han Kuo, M.D.
Columbia University

Tremor is a prevalent and often debilitating disorder for many individuals; however, the cause of tremor remains poorly understood. We have previously identified alterations in the cerebellum, the brain region important for motor coordination, in tremor patients. Now, we will study the relationship between this brain pathology and tremor by establishing a mouse model with similar pathological alterations in the cerebellum. We will study tremor characteristics and the alterations of neuronal activities in this novel mouse model, and we will further identify ways that could suppress or enhance tremor by pharmacology and neuromodulation. To further understand how tremor is generated from the abnormal neuronal connections in the brain, we will use novel neuroscience tools to specifically suppress neuronal activities or to disrupt neuronal connections and assess how these manipulations could influence tremor and the abnormal neuronal activities. The results of our proposal will establish a new platform to screen drug therapies for tremor.

Other Grants

Andre Berndt, Ph.D.
Monitoring Communication in Neuronal Networks in Real Time and at Single Cell Resolution
Visualizing the flow of information through the complex and intertwined networks of the brain is a long‐sought goal of neuroscience. Genetically encoded proteins such as the fluorescent calcium sensor GCaMP…
Denise Cai, Ph.D.
Investigating the Role of Negative Valence in the Temporal Dynamics of Memory-Linking
Determining how distinct memories are formed, linked, and retrieved, and the role of fear in these processes, is an essential part of understanding PTSD, a debilitating disorder characterized by the…
Dr. Weizhe Hong, Ph.D.
Dissecting the Organization and Function of Social Behavioral Circuits in the Amygdala
Social interactions play a crucial role in the reproduction, survival, and physical and mental health of many vertebrate species including humans. Impairment in social behavior is a hallmark of several…
Takashi Kitamura, Ph.D.
Neural Circuit Mechanisms of Behavior-Dependent Representation for Space and Time
The central question in my proposal is whether our perception of time and space share the same circuit mechanisms during our daily life. Recent studies suggest that neurons in the…