Active dendritic processing of sensory inputs in vivo

2019 Seed Grant
Ikuko Smith, Ph.D.
University of California, Santa Barbara

During sensory perception, neural circuitry processes information by filtering, amplifying, and integrating electrical signals. The proposed project focuses on uncovering the underpinnings of such processes using electrophysiology, brain imaging, and behavioral analyses. The key aim of the project is to understand the role of neuronal dendrites in processing information. Much like axons, dendrites are capable of firing electrical spikes. Such capacity for spiking allows dendrites to serve as mini-computational units akin to transistors rather than passive cables. This concept vastly increases the computational power of a single neuron. If one imagines a network of neuronal connectivity as infrastructure like roads in the city, computational units on the dendrites would be the traffic lights that flexibly control the flow of the informational traffic. Whether such an active mechanism is engaged and plays a functional role in a behaving animal remains unclear. By directly recording electrical activities from fine distal dendrites during visual behavior, we seek to understand how dendrites contribute to synaptic computations and how modifying their excitability affects sensory integration. There are numerous developmental cognitive deficits such as autism that co-manifest with dysfunction in higher sensory perception. Findings from the project will both further our understanding of the fundamental way in which our brain processes information and help us study sensory integration as a foothold to decipher a general way in which a neural circuit is affected in these disorders.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…