Age-related macular degeneration (AMD) by Agnella Matic

Characterization of infrared neural stimulation in the retina
2012 Seed Grant
Agnella Matic, Ph.D.
Department of Otolaryngology
Northwestern University

Age-related macular degeneration (AMD) is the most common cause of visual impairment in Americans over the age of 60.  Every year, 700,000 new cases of AMD are diagnosed and 10% of those patients will become legally blind.  Unfortunately, there are no cures for AMD and, at best, current treatments only slow the disease progression.  Retinitis pigmentosa is a vision-loss disorder estimated to affect 100,000 individuals in the US, for whom there is no effective treatment at this time.  The overall economic impact of these visual impairments is significant. Visual prostheses aim to restore sight to individuals who have severe visual impairments as a result of AMD and RP. However, at best, the patients using visual prostheses can only distinguish large objects with high contrast (i.e. a dark-colored door in a white room).  The limitations of the prostheses are possibly due to the lack of precision in the electrical stimulation of the nerves in the eye.  We can achieve much more specific stimulation of nerves using lasers.  Dr. Matic will use her 2012 Seed Grant to use lasers to stimulate nerves in the eye as an alternative technology for visual prostheses.  The ultimate goal of this project is to build a laser-based prosthesis for the eye that affords the patient a significant increase in their quality of life.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…