Alzheimer’s disease

Structures, stabilities, and formation kinetics of amyloid beta precursors and oligomers
2013 Seed Grant

Yongli Zhang, Ph.D.
Department of Cell Biology
Yale University

Alzheimer’s disease (AD) is a prevailing disease with no treatment. AD is caused by imbalanced production and clearance of Abeta peptides in the brain, leading to neurotoxic Abeta oligomers. Current efforts to treat AD have been focused on reducing Abeta production and oligomerization. Yet both processes are not well understood, despite extensive research in the past decades based on the traditional experimental approaches typically with over a billion molecules. Dr. Zhang’s lab proposes to characterize the dynamical structures and stabilities of Abeta precursors and oligomers at a single molecule level, using combined single-molecule approaches. They believe that the novel approaches will provide significant new insights into AD pathogenesis, diagnosis, and therapy.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the Nervous System Constructs Internal Models of the External World
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…