Alzheimer’s disease

Structures, stabilities, and formation kinetics of amyloid beta precursors and oligomers
2013 Seed Grant

Yongli Zhang, Ph.D.
Department of Cell Biology
Yale University

Alzheimer’s disease (AD) is a prevailing disease with no treatment. AD is caused by imbalanced production and clearance of Abeta peptides in the brain, leading to neurotoxic Abeta oligomers. Current efforts to treat AD have been focused on reducing Abeta production and oligomerization. Yet both processes are not well understood, despite extensive research in the past decades based on the traditional experimental approaches typically with over a billion molecules. Dr. Zhang’s lab proposes to characterize the dynamical structures and stabilities of Abeta precursors and oligomers at a single molecule level, using combined single-molecule approaches. They believe that the novel approaches will provide significant new insights into AD pathogenesis, diagnosis, and therapy.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…