Alzheimer’s disease by Yongli Zhang

Structures, stabilities, and formation kinetics of amyloid beta precursors and oligomers
2013 Seed Grant

Yongli Zhang, Ph.D.
Department of Cell Biology
Yale University

Alzheimer’s disease (AD) is a prevailing disease with no treatment. AD is caused by imbalanced production and clearance of Abeta peptides in the brain, leading to neurotoxic Abeta oligomers. Current efforts to treat AD have been focused on reducing Abeta production and oligomerization. Yet both processes are not well understood, despite extensive research in the past decades based on the traditional experimental approaches typically with over a billion molecules. Dr. Zhang’s lab proposes to characterize the dynamical structures and stabilities of Abeta precursors and oligomers at a single molecule level, using combined single-molecule approaches. They believe that the novel approaches will provide significant new insights into AD pathogenesis, diagnosis, and therapy.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…