Autism Spectrum Disorder

Is there a cerebellar component of autism? A study using the ‘Chromosome 7 duplicated’ (Dup) mouse model
2011 Seed Grant
Christian Hansel, Ph.D.
Department of Neurobiology
University of Chicago

Autism Spectrum Disorder (ASD) is a brain disorder with devastating consequences for social interaction skills, which is further characterized by repetitive behavior and language impairment. Here, we want to test the hypothesis that specific ASD components, such as deficits in verbal fluency and categorization learning, are related to impaired cerebellar learning and plasticity. To this end, we will perform patch-clamp recordings and fluorescence imaging experiments to examine whether synaptic memory mechanisms in the cerebellum are dysfunctional in an established mouse model of autism.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
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Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…