Beyond Neurotransmission: Exploring Roles for Synaptic Dopaminylation in Drug-induced Plasticity

2017 Seed Grant
Ian Maze, Ph.D.
Icahn School of Medicine at Mount Sinai

Substance use disorder is a chronic, relapsing illness that affects millions of individuals worldwide; however, few effective treatment options for substance abuse and addiction exist. Here, employing a unique combination of biochemical, molecular and behavioral approaches, we examine a highly novel role for the neurotransmitter dopamine in the direct regulation of protein function at reward circuitry synapses, processes that likely contribute to addictive behaviors. This pilot proposal therefore aims to transformatively integrate expertise from multiple disciplines (e.g., chromatin biochemistry, neuroepigenetics and behavioral neuroscience) to begin characterizing so-called protein “dopaminylation” in the central nervous system, as well as to elucidate its potential role in compulsive cocaine seeking. The overarching goal of this work is thus to identify novel molecular underpinnings of life-long addiction that will allow for the development of more effective therapeutic interventions.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…