Cancer Treatment

Advanced bio-inorganic materials for targeted thermal & photodynamic glioblastoma multiforme therapy
2007 Women’s Council Seed Grant
Elena Rozhkova, Ph.D.
The University of Chicago

In this project new strategies of Glioblastoma multiforme therapy on the base of designed magnetic or semiconductor bio-nano materials are proposed. Biocompatible magnetic particles or nanoscaled semiconductor titanium oxide will be fabricated and functionalized for clinically applicable directed cancer targeting and use in magnetic hyperthermia or photodynamic cancer therapy.

The long term goal of the proposal is to utilize biomedical nanoengineering to improve the outcome of cancer patients. Cancer is the 2nd leading cause of death in the US and about 2.5 million new cases are diagnosed every year, with about ~500,000 Americans dying annually, that is, >1,500 people/day. Advancing the treatment options for cancer therapy may not only improve the quality of life for an individual patient but also have a tremendous socioeconomic impact on our Nation, as even small, incremental advances in cancer survival and disability will inevitably lead to a large health care benefit. Specifically, it is anticipated that with the completion of the proposed research Dr. Rozhkova will have obtained the critical preliminary data needed to support the rational design and fabrication of novel magnetic materials for targeted cancer treatment.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the Nervous System Constructs Internal Models of the External World
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…