Cancer Treatment

Advanced bio-inorganic materials for targeted thermal & photodynamic glioblastoma multiforme therapy
2007 Women’s Council Seed Grant
Elena Rozhkova, Ph.D.
The University of Chicago

In this project new strategies of Glioblastoma multiforme therapy on the base of designed magnetic or semiconductor bio-nano materials are proposed. Biocompatible magnetic particles or nanoscaled semiconductor titanium oxide will be fabricated and functionalized for clinically applicable directed cancer targeting and use in magnetic hyperthermia or photodynamic cancer therapy.

The long term goal of the proposal is to utilize biomedical nanoengineering to improve the outcome of cancer patients. Cancer is the 2nd leading cause of death in the US and about 2.5 million new cases are diagnosed every year, with about ~500,000 Americans dying annually, that is, >1,500 people/day. Advancing the treatment options for cancer therapy may not only improve the quality of life for an individual patient but also have a tremendous socioeconomic impact on our Nation, as even small, incremental advances in cancer survival and disability will inevitably lead to a large health care benefit. Specifically, it is anticipated that with the completion of the proposed research Dr. Rozhkova will have obtained the critical preliminary data needed to support the rational design and fabrication of novel magnetic materials for targeted cancer treatment.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…