Functional characterization of genes associated with Obsessive Compulsive Disorder using mouse models

2014 Seed Grant
Stephanie Dulawa, Ph.D.
Department of Psychiatry and Behavioral Neuroscience
The University of Chicago

This work will determine mechanisms by which BTBD3, the first gene associated with human OCD by GWAS, influences OCD-related behaviors in mice. In addition to the results we will obtain during the one year funding period, this work will generate critical tools for obtaining future NIH funding. Identifying when and where in the brain BTBD3 regulates OCD-related behaviors will provide novel insights into the molecular mechanisms underlying OCD. Furthermore, this work could lead to novel drug treatments for OCD, which are sorely needed. We plan to submit data obtained from this work for publication within 3 months of project completion. In summary, this work could advance our understanding of the etiology and pathophysiology of OCD, and lead to novel treatments.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…