Functional characterization of genes associated with Obsessive Compulsive Disorder using mouse models

2014 Seed Grant
Stephanie Dulawa, Ph.D.
Department of Psychiatry and Behavioral Neuroscience
The University of Chicago

This work will determine mechanisms by which BTBD3, the first gene associated with human OCD by GWAS, influences OCD-related behaviors in mice. In addition to the results we will obtain during the one year funding period, this work will generate critical tools for obtaining future NIH funding. Identifying when and where in the brain BTBD3 regulates OCD-related behaviors will provide novel insights into the molecular mechanisms underlying OCD. Furthermore, this work could lead to novel drug treatments for OCD, which are sorely needed. We plan to submit data obtained from this work for publication within 3 months of project completion. In summary, this work could advance our understanding of the etiology and pathophysiology of OCD, and lead to novel treatments.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…