Functional characterization of genes associated with Obsessive Compulsive Disorder using mouse models

2014 Seed Grant
Stephanie Dulawa, Ph.D.
Department of Psychiatry and Behavioral Neuroscience
The University of Chicago

This work will determine mechanisms by which BTBD3, the first gene associated with human OCD by GWAS, influences OCD-related behaviors in mice. In addition to the results we will obtain during the one year funding period, this work will generate critical tools for obtaining future NIH funding. Identifying when and where in the brain BTBD3 regulates OCD-related behaviors will provide novel insights into the molecular mechanisms underlying OCD. Furthermore, this work could lead to novel drug treatments for OCD, which are sorely needed. We plan to submit data obtained from this work for publication within 3 months of project completion. In summary, this work could advance our understanding of the etiology and pathophysiology of OCD, and lead to novel treatments.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the Nervous System Constructs Internal Models of the External World
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…