Huntington’s disease, OCD, Parkinson’s disease

Optogenetic dissection of the striatal subcircuits during action sequence learning
2013 Seed Grant

Xin Jin, Ph.D.
Department of Molecular Neurobiology Laboratory
The Salk Institute for Biological Studies

Many neurological and psychiatric disorders including Parkinson’s disease, Huntington’s disease and obsessive-compulsive disorder are related to the basal ganglia dysfunction. The basal ganglia circuits consist of two major subcircuits, called direct and indirect pathways. Traditionally, it was thought that these two pathways work antagonically to facilitate and inhibit actions respectively, and imbalance of them would lead to basal ganglia dysfunction and action disorders. Dr. Jin’s project aims to study the physiology and function of these two pathways in vivo, and validate the classic basal ganglia functional model within a complex behavior context. The findings from this project will not only reveal the fundamental organization of action in the basal ganglia circuits, but also provide important insights into the pathology of many basal ganglia related action disorders.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…