Learning and Memory

A hallmark feature of our brains is their enormous capacity for information storage and learning. In neuronal circuits, information is stored through long-term changes in the efficacy and gain of synaptic communication, as in long-term potentiation (LTP) and long-term depression (LTD). But what mediates the changes in synaptic gain? Are they due to changes in response properties of individual transmitter receptors, or by changes in the number and density of receptors at the synapses? Recent studies using neuronal cultures suggest that trafficking of receptors in and out of the synaptic membrane regulates synaptic gain. A caveat of these experiments is that cultures keep neurons ‘locked’ in an early developmental stage. Using a combination of patch-clamp recordings and imaging techniques, we want to examine whether glutamate receptor trafficking also plays a key role in synaptic memory storage in the adult brain.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…