Mental Retardation

In Vivo Analysis of the Role of FMRP in Dendrite Maturation and Plasticity in the
Somatosensory Cortex

2009 Seed Grant
Anis Contractor, Ph.D.
Northwestern University

Fragile X syndrome is the most common form of human mental retardation and the single
largest known cause of autism. One prominent manifestation of the disease is an alteration in
sensory processing that results in tactile hypersensitivity in fragile X patients. This study will
seek to define the impairments in dendritic maturation and plasticity in the sensory cortex of a
fragile X mouse model. The results will allow us to determine the role that fragile X mental
retardation protein plays in the development and plasticity of neurons which underlie sensory
processing.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…