Neuron Development

N-cadherin regulation of the adult neural stem cell niche
2011 Seed Grant
Anjen Chenn, M.D., Ph.D.
Department of Pathology
Northwestern University

Neural stem and progenitor cells generate the massive diversity of neurons and glia that comprise the nervous system. Understanding the regulation of how neural progenitors divide and differentiate will provide important insight into disease mechanisms and enable the development of new therapeutic approaches. Our previous studies in the developing cerebral cortex suggest that stem and progenitor cells can support the growth and differentiation of other stem and progenitor cells. The goals of this proposal are to examine whether similar support mechanisms exist in the adult brain, and to elucidate the mechanisms by which cell adhesion may regulate the adult neural stem cell microenvironment. We will use mouse models of brain development for these studies.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…