Neuron Development by Anjen Chenn

N-cadherin regulation of the adult neural stem cell niche
2011 Seed Grant
Anjen Chenn, M.D., Ph.D.
Department of Pathology
Northwestern University

Neural stem and progenitor cells generate the massive diversity of neurons and glia that comprise the nervous system. Understanding the regulation of how neural progenitors divide and differentiate will provide important insight into disease mechanisms and enable the development of new therapeutic approaches. Our previous studies in the developing cerebral cortex suggest that stem and progenitor cells can support the growth and differentiation of other stem and progenitor cells. The goals of this proposal are to examine whether similar support mechanisms exist in the adult brain, and to elucidate the mechanisms by which cell adhesion may regulate the adult neural stem cell microenvironment. We will use mouse models of brain development for these studies.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…