Parkinson’s Disease

The Developmental Basis of Dopaminergic Neuron Diversity
2010 Seed Grant
Rajeshwar Awatramani, Ph.D.
Department of Neurology
Northwestern University

Dr. Awatramani proposes that there is a developmental basis for dopamine neuron diversity. In other words, during embryonic development, the dopamine progenitor pool is parceled in a manner meaningful to later dopamine subtype identity. Elucidating the developmental basis for this diversity will be critical for understanding differential susceptibility of dopamine neurons in Parkinson’s disease (PD), as well as generating accurate Embryonic Stem cell or induced Pluripotent Stem cell derived models and therapies for PD. Indeed, this has been identified as a priority by stem cell scientists in the field of PD (3).

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…