Periventricular Heterotopia (PH)

Periventricular Heterotopia (PH) caused by mutations of the Filamin gene is a congenital brain developmental disease that affects both brain structures and functions. A mouse model of PH by inactivating Filamin is described in this proposal to study the pathogenesis of PH. Preliminary analyses suggested that losing Filamin resulted in altered neural stem cell functions which led to abnormal production of neurons in the diseased brain. Further studies are proposed to analyze the time, location and cause of abnormal neuron generations in the mouse model to learn how neural stem cells are regulated by Filamin, and how to control the behaviors of neural stem cells.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…