Periventricular Heterotopia (PH)

Periventricular Heterotopia (PH) caused by mutations of the Filamin gene is a congenital brain developmental disease that affects both brain structures and functions. A mouse model of PH by inactivating Filamin is described in this proposal to study the pathogenesis of PH. Preliminary analyses suggested that losing Filamin resulted in altered neural stem cell functions which led to abnormal production of neurons in the diseased brain. Further studies are proposed to analyze the time, location and cause of abnormal neuron generations in the mouse model to learn how neural stem cells are regulated by Filamin, and how to control the behaviors of neural stem cells.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…