Rethinking Remyelination: The Role of Mature Oligodendrocytes in Remyelination

2021 Seed Grant
Ethan G. Hughes, Ph.D.
University of Colorado

Can the adult brain regenerate? Finding the answer to this question is an overarching goal of the field of neuroscience. Recently, our laboratory found a new type of regeneration in the adult brain. This regeneration is driven by mature oligodendrocytes, the myelinating cells of the central nervous system (CNS). However, whether this process can be used to promote recovery of patients with Multiple Sclerosis (MS) is unclear. This proposal will use a combination of advanced imaging, a clinically-relevant demyelination model, and single cell RNA sequencing guided by lineage-mapping, to understand the cell biology underlying mature oligodendrocyte regeneration. Results from this program will provide insights into whether specific genetic pathways within mature oligodendrocytes can be targeted to promote recovery from MS, a debilitating neurological disorder that affects millions of people worldwide.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…