Rethinking Remyelination: The Role of Mature Oligodendrocytes in Remyelination

2021 Seed Grant
Ethan G. Hughes, Ph.D.
University of Colorado

Can the adult brain regenerate? Finding the answer to this question is an overarching goal of the field of neuroscience. Recently, our laboratory found a new type of regeneration in the adult brain. This regeneration is driven by mature oligodendrocytes, the myelinating cells of the central nervous system (CNS). However, whether this process can be used to promote recovery of patients with Multiple Sclerosis (MS) is unclear. This proposal will use a combination of advanced imaging, a clinically-relevant demyelination model, and single cell RNA sequencing guided by lineage-mapping, to understand the cell biology underlying mature oligodendrocyte regeneration. Results from this program will provide insights into whether specific genetic pathways within mature oligodendrocytes can be targeted to promote recovery from MS, a debilitating neurological disorder that affects millions of people worldwide.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the Nervous System Constructs Internal Models of the External World
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…