Schizophrenia

The late-adolescent onset of psychiatric and addiction-related syndromes is strongly linked to the sensitive period of prefrontal cortex (frontal lobe) maturation during adolescence. However, the neurodevelopmental processes that determine this vulnerability are currently unknown. Among the different neurotransmitter candidates thought to confer predisposition to the adolescent liability, the brain CB1 cannabinoid receptor, which mediates the psychoactive effects of marihuana (cannabis), is of particular interest due to recent studies showing that marihuana abuse during adolescence significantly increase the risk of developing schizophrenia later in life. Interestingly, CB1 receptors are highly expressed in the prefrontal cortex. What is missing is the mechanistic link between the effects of repeated cannabinoid exposure during adolescence and the development of prefrontal cortex dysfunction. Thus, the goal of Dr. Tseng’s study is to establish such a mechanistic link by determining whether repeated activation of the CB1 receptor limited to the adolescent period is sufficient to impair the normal maturation of the prefrontal cortex network, and its association with prefrontal-related behavioral deficits in adulthood.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…