Spinocerebellar ataxia

Epigenetics in Spinocerebellar Ataxia
2009 Seed Grant
Puneet Opal, M.D., Ph.D.
Northwestern University

Our lab is interested in understanding events that lead to chronic degenerative diseases that affect the brain. Currently we are studying a genetic disease that leads to cerebellar pathology called Spinocerebellar Ataxia Type 1. This disease is caused by a mutation in a gene that lead to an expansion of glutamines (an amino acid) in the protein encoded by this gene. One leading hypothesis is that the diseased protein leads to changes in gene expression that causes deleterious events. Our lab is trying to identify the mechanisms underlying these changes in gene expression so as to lead to future avenues of therapy. The BRF seed grant will be crucial in providing my lab with the funds to obtain more preliminary data to compete for R01 level funding from the NIH.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…