Synaptic Vesicle Biogenesis – Linked to Alzheimer’s Disease, Parkinson’s Disease and Down Syndrome

The Regulation of Dynamin and Actin Polymerization in Endocytic Vesicle Biogenesis
2010 Seed Grant
Liang-Wei Gong, Ph.D.
Department of Biological Sciences
University of Illinois at Chicago

The results of this work will provide new insights into the molecular mechanisms of vesicle fission during CME. I expect that my research will significantly contribute to our knowledge of brain function, as synaptic vesicle recycling is a fundamental event mediating higher functions of the brain such as learning and memory. This work will also make general contributions to cell biology, as CME is the main form of endocytosis in many types of cells. The results from this proposal will likely have broad implications for human health, as impaired vesicle recycling is also linked to many human diseases such as Type II Diabetes, Parkinson’s disease, Alzheimer’s disease and Down syndrome.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…