Synaptic Vesicle Biogenesis – Linked to Alzheimer’s Disease, Parkinson’s Disease and Down Syndrome

The Regulation of Dynamin and Actin Polymerization in Endocytic Vesicle Biogenesis
2010 Seed Grant
Liang-Wei Gong, Ph.D.
Department of Biological Sciences
University of Illinois at Chicago

The results of this work will provide new insights into the molecular mechanisms of vesicle fission during CME. I expect that my research will significantly contribute to our knowledge of brain function, as synaptic vesicle recycling is a fundamental event mediating higher functions of the brain such as learning and memory. This work will also make general contributions to cell biology, as CME is the main form of endocytosis in many types of cells. The results from this proposal will likely have broad implications for human health, as impaired vesicle recycling is also linked to many human diseases such as Type II Diabetes, Parkinson’s disease, Alzheimer’s disease and Down syndrome.

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Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…