Synaptic Vesicle Biogenesis – Linked to Alzheimer’s Disease, Parkinson’s Disease and Down Syndrome

The results of this work will provide new insights into the molecular mechanisms of vesicle fission during CME. I expect that my research will significantly contribute to our knowledge of brain function, as synaptic vesicle recycling is a fundamental event mediating higher functions of the brain such as learning and memory. This work will also make general contributions to cell biology, as CME is the main form of endocytosis in many types of cells. The results from this proposal will likely have broad implications for human health, as impaired vesicle recycling is also linked to many human diseases such as Type II Diabetes, Parkinson’s disease, Alzheimer’s disease and Down syndrome.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…