Archives: Grants

Christian Peters, Ph.D. University of Illinois at Chicago

Mu-opioid Receptor Regulation by Golgi Satellites in Opioid Use Disorder

Opioid use disorder has become a major health crisis in the US as a result of over-prescription of addictive opiate-derived analgesics. Opioids form a strong physical interaction with mu-opioid receptors in the brain. These receptors are highly expressed in the reward circuitry of the brain, and ...

Akhila Rajan, Ph.D., Fred Hutchinson Cancer Research Center

Fat to Brain Communication: Inter-organ Transport of Mitochondrial Molecules

Increased life expectancy has resulted in a higher incidence of age-related dementia, but treatments remain elusive. Obesity has been established as an independent risk factor for developing dementia. Yet, the mechanisms by which increased mid-life adiposity contributes to neuronal dysregulation,...

Johannes Schöneberg, Ph.D. University of California, San Diego

The Role of 4D Mitochondrial Morphology in Impaired Neurogenesis

Neurogenesis is the process in which the neuronal cells of the brain are created from stem cells. In embryos, problems with neurogenesis lead to severe embryonal defects and mental disabilities in children such as learning and memory disabilities, seizures and even death. In adults, impaired neur...

Nilay Yapici, Ph.D., Cornell University

Neural Dynamics of Taste and Hunger Integration in the Mammalian Brainstem

Food intake is influenced by many factors such as physiological, social, emotional, and contextual settings. The neural circuits that regulate hunger, satiety, and food intake have been extensively studied in vertebrate models. These studies have identified many regions that impact food intake an...

Lindsay M. De Biase, Ph.D., University of California Los Angeles

The Role of Microglial Lysosomes in Selective Neuronal Vulnerability

Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are more vulnerable to synapse dysfunction, synapse loss, and neurodegenerative disease during aging.

Stephen W. Flavell, Ph.D., MIT

How the Nervous System Constructs Internal Models of the External World

As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into active neural representations of the external world is a fundamental building block of intell...

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