Archives: Grants

Sung Han, Ph.D., Salk Institute for Biological Studies

The Neural Basis of Opioid-induced Respiratory Depression

Opioids are the most commonly used and most effective analgesics, and are the first line of defense against acute and severe pain. However, this dramatic ability to mitigate pain comes with many side effects. These include constipation, nausea, sedation, dizziness, respiratory depression, depende...

Anirvan S. Nandy, Ph.D., Yale University

A New Paradigm for the Neuroscience of Navigation

How do social interactions dynamically shape the neural circuits of cognition? Maps of the physical and social environment (“cognitive maps”) in the brain have been theorized to be central to cognition. In highly social species like humans, cognitive computations frequently occur in s...

Won Chan Oh, Ph.D., University of Colorado

Role of Inhibitory Synapses in Shaping Excitatory Circuits

How memories are encoded in the brain is a central question in neuroscience. Our capacity to learn and recall past events is of extreme importance and loss of this ability is a hallmark feature of numerous devastating neurological disorders such as Alzheimer’s disease.

Cody A. Siciliano, Ph.D., Vanderbilt University

Neural Mechanisms of Inferential Learning

The ability to make advantageous choices in uncertain situations is a fundamental behavioral process that allows for maximizing positive outcomes while minimizing negative ones. Many species are able to streamline this process by applying learned strategies to optimize choices in contexts that ha...

Robert A. Hill, Ph.D., Dartmouth College

Mechanisms of Myelin Degeneration and Clearance in the Live Brain

A complex cell structure called myelin has evolved to speed up and finely tune the transmission of electrical signals in the brain. In numerous human diseases, myelin is damaged and must be removed before tissue repair can occur.

Kai Miller, M.D., Ph.D., Mayo Clinic

An Implanted Brain-computer Interface for ALS Patients

Implanted brain-computer interfaces (BCls) recently made the jump from a tool requiring a custom hardware setup at the bedside and the full-time assistance of a scientist, to a small off-the-shelf implant that can be used independently to control programs on a tablet without assistance.

Ikuko Smith, Ph.D., University of California, Santa Barbara

Active dendritic processing of sensory inputs in vivo

During sensory perception, neural circuitry processes information by filtering, amplifying, and integrating electrical signals. The proposed project focuses on uncovering the underpinnings of such processes using electrophysiology, brain imaging, and behavioral analyses.

Kathleen Smith, Ph.D., University of Colorado, Denver

Excitatory and inhibitory synapse communication in synaptic plasticity

During many neurological diseases, brain regions that are essential for learning and memory become over-excitable, due to excessive nerve impulses between nerve cells. This causes nerve cells in these regions to behave abnormally or die, leading to brain damage.

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