Vision by David Freedman

Neuronal Mechanisms of Visual Category Learning and Recognition
2008 Seed Grant
David Freedman, Ph.D.
University of Chicago

Humans and other advanced animals are not born with a built in library of meaningful
categories, such as “tables” and “chairs,” which we are preprogrammed to recognize. Instead
we learn to recognize the meaning of such stimuli through experience. This ability, which is
disrupted by a number of brain diseases and conditions such as Alzheimer’s disease,
schizophrenia and stroke, is critical because it allows us to respond appropriately to the
continuous stream of stimuli and events that we encounter in our interactions with the
environment.

While much is known about the encoding of basic visual features (such as contrast, orientation,
and motion direction) in early stages of the visual system, much less is known about how the
brain learns, stores, recognizes and recalls the meaning of our sensory experiences. With his
2008 Brain Research Foundation Seed Grant, Dr. David J. Freedman conducted research to
determine a more detailed understanding of the brain mechanisms of visual learning, memory
and recognition.

A greater understanding of visual learning and categorization is important for addressing a
number of brain disorders and conditions that leave patients impaired in everyday tasks that
require an appropriate response to sensory information. These studies also have particular
relevance for understanding and addressing learning disabilities, such as attention deficit
disorder and dyslexia, which affect a substantial number of school age children and young
adults. The long-term goal of Dr. Freedman’s research is to help guide the next generation of
treatments for these brain-based diseases and disorders by helping to develop a detailed
understanding of the brain mechanisms that underlie learning, memory and recognition.

Results from this study enabled Dr. Freedman to submit a proposal to the National Science
Foundation (NSF). In 2010, Dr. Freedman was awarded the NSF CAREER award for junior
faculty. This award is a five year grant in the amount of $950,000.

The NSF is an independent federal agency that supports all fields of fundamental science and
engineering.

Dr. David Freedman’s 2008 BRF Seed Grant award leads to a $950,000 grant from the National
Science Foundation.

Other Grants

José Manuel Baizabal Carballo, Ph.D., Indiana University Bloomington
Heterochromatin Mechanisms of Cortical Expansion
Neurodevelopmental disorders, such as autism and schizophrenia, are frequently associated with mutations in genes that encode chromatin-modifying enzymes. A subset of these mutations is thought to disrupt compacted chromatin (heterochromatin),…
Jessica L. Bolton, Ph.D., Georgia State University
Chemogenetic Tools in Microglia as a Novel Therapeutic Approach for Brain Disorders
All humans are born with a unique combination of genes, which contribute greatly to who we are. However, early-life experiences such as trauma or hardship, particularly during the first few…
Junyue Cao, Ph.D., The Rockefeller University
Elucidate the Molecular and Cellular Targets of Caloric Restriction in Rejuvenating Aged Mammalian Brain
As we age, the brain’s ability to function declines, increasing the risk of cognitive impairments and neurological diseases like Alzheimer’s and Parkinson’s. Our research investigates how caloric restriction (CR), a…
Vasileios Christopoulos, Ph.D., University of Southern California
Understanding the Mechanisms of Micturition in the Brain and Spinal Cord
This research aims to better understand how the brain and spinal cord work together to control urination, a process known as micturition. In healthy individuals, this process is carefully coordinated…