Dopaminergic Mechanisms of Social Cooperation and Observational Learning

2024 Seed Grant
Jesse H. Goldberg, M.D., Ph.D.
Cornell University

Parenting is hard work. Humans and other animals have to care not only for themselves but also for needy young. Here we examine brain mechanisms of parenting in songbirds. Mammals feed their young through nursing, but songbirds must go out and find food and return to the nest and actively feed their young by placing food into their chicks’ open beaks. How do birds know how to do this? Here we test if songbirds get rewarded by internal brain dopamine systems for feeding their chicks. It’s already known that when a hungry animal (including a bird or a human) gets food reward, there is a burst of dopamine in its brain. We recently developed methods to measure brain dopamine signals in birds, so now we can test if the same burst of dopamine occurs when a parent successfully gives food way to its chick. Overall, we are testing if altruistic behaviors – where animals do work for others – can re-use existing brain pathways for serving oneself.
 

Other Grants

José Manuel Baizabal Carballo, Ph.D., Indiana University Bloomington
Heterochromatin Mechanisms of Cortical Expansion
Neurodevelopmental disorders, such as autism and schizophrenia, are frequently associated with mutations in genes that encode chromatin-modifying enzymes. A subset of these mutations is thought to disrupt compacted chromatin (heterochromatin),…
Jessica L. Bolton, Ph.D., Georgia State University
Chemogenetic Tools in Microglia as a Novel Therapeutic Approach for Brain Disorders
All humans are born with a unique combination of genes, which contribute greatly to who we are. However, early-life experiences such as trauma or hardship, particularly during the first few…
Junyue Cao, Ph.D., The Rockefeller University
Elucidate the Molecular and Cellular Targets of Caloric Restriction in Rejuvenating Aged Mammalian Brain
As we age, the brain’s ability to function declines, increasing the risk of cognitive impairments and neurological diseases like Alzheimer’s and Parkinson’s. Our research investigates how caloric restriction (CR), a…
Vasileios Christopoulos, Ph.D., University of Southern California
Understanding the Mechanisms of Micturition in the Brain and Spinal Cord
This research aims to better understand how the brain and spinal cord work together to control urination, a process known as micturition. In healthy individuals, this process is carefully coordinated…