Probing Plasticity Mechanisms of Engram Formation with All-Optical Physiology

2025 Seed Grant
Linlin Fan, Ph.D.
Massachusetts Institute of Technology

Our research focuses on understanding how the brain stores memories. We are studying special groups of brain cells, called engrams, that help us remember things. These memory cells become active when we learn something new, but scientists don’t fully understand how they change or connect to form a memory. We will use optical tools that allow us to see and control the activity of brain cells with light. This will help us discover exactly how memory cells work and what changes happen when a memory is formed. This knowledge could help us better understand and eventually treat brain diseases that affect memory, like Alzheimer’s disease.

Other Grants

José Manuel Baizabal Carballo, Ph.D., Indiana University Bloomington
Heterochromatin Mechanisms of Cortical Expansion
Neurodevelopmental disorders, such as autism and schizophrenia, are frequently associated with mutations in genes that encode chromatin-modifying enzymes. A subset of these mutations is thought to disrupt compacted chromatin (heterochromatin),…
Jessica L. Bolton, Ph.D., Georgia State University
Chemogenetic Tools in Microglia as a Novel Therapeutic Approach for Brain Disorders
All humans are born with a unique combination of genes, which contribute greatly to who we are. However, early-life experiences such as trauma or hardship, particularly during the first few…
Junyue Cao, Ph.D., The Rockefeller University
Elucidate the Molecular and Cellular Targets of Caloric Restriction in Rejuvenating Aged Mammalian Brain
As we age, the brain’s ability to function declines, increasing the risk of cognitive impairments and neurological diseases like Alzheimer’s and Parkinson’s. Our research investigates how caloric restriction (CR), a…
Vasileios Christopoulos, Ph.D., University of Southern California
Understanding the Mechanisms of Micturition in the Brain and Spinal Cord
This research aims to better understand how the brain and spinal cord work together to control urination, a process known as micturition. In healthy individuals, this process is carefully coordinated…