A Modular System for Temporal and Cell-type Specific Manipulation of Neural Circuits

2019 Seed Grant
Tiffany Schmidt, Ph.D.
Northwestern University

Women’s Council Seed Grant

One major hurdle to treating diseases affecting vision is a fundamental lack of understanding of how light signals sent from the retina influence our behavior and physiology. In the proposed work, we will develop a suite of genetic tools to label, manipulate, and ablate specific subsets of retinal neurons at specific times. These tools have the potential to expand our understanding of the basic functions and wiring of the visual system in health and how this signaling goes wrong in disease. Most importantly, these tools will be made available to the wider neuroscience community where they could aid in the understanding of how specific neuronal cell types contribute to neurodegenerative diseases, neurodevelopmental disorders, and mental health issues.

Other Grants

José Manuel Baizabal Carballo, Ph.D., Indiana University Bloomington
Heterochromatin Mechanisms of Cortical Expansion
Neurodevelopmental disorders, such as autism and schizophrenia, are frequently associated with mutations in genes that encode chromatin-modifying enzymes. A subset of these mutations is thought to disrupt compacted chromatin (heterochromatin),…
Jessica L. Bolton, Ph.D., Georgia State University
Chemogenetic Tools in Microglia as a Novel Therapeutic Approach for Brain Disorders
All humans are born with a unique combination of genes, which contribute greatly to who we are. However, early-life experiences such as trauma or hardship, particularly during the first few…
Junyue Cao, Ph.D., The Rockefeller University
Elucidate the Molecular and Cellular Targets of Caloric Restriction in Rejuvenating Aged Mammalian Brain
As we age, the brain’s ability to function declines, increasing the risk of cognitive impairments and neurological diseases like Alzheimer’s and Parkinson’s. Our research investigates how caloric restriction (CR), a…
Vasileios Christopoulos, Ph.D., University of Southern California
Understanding the Mechanisms of Micturition in the Brain and Spinal Cord
This research aims to better understand how the brain and spinal cord work together to control urination, a process known as micturition. In healthy individuals, this process is carefully coordinated…