A Novel Whole-brain Method for In Vivo Imaging of Progressive Neurodegeneration

2018 Seed Grant
David Schoppik, Ph.D.
New York School of Medicine

Neurodegenerative disorders arise as components of the nervous system deteriorate with age. The symptoms accompanying this deterioration become progressively worse, compromising an individual’s ability to function. The progressive and widespread nature of neurodegenerative diseases pose particular challenges to understanding the mechanisms responsible. While considerable progress has been made at the molecular level, how these biochemical events lead to clinical symptoms remains poorly understood. Here we propose to develop a powerful new model system to study progressive neurodegeneration. We will induce neurodegeneration and use cutting-edge non-invasive imaging technology to make longitudinal measurements of brain function. Simultaneously we will monitor emergent symptoms with quantitative measures of behavior. Our aim is to reveal mechanisms of progressive dysfunction and build a framework to one day evaluate therapeutic approaches.

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Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
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Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
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Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…