A Novel Whole-brain Method for In Vivo Imaging of Progressive Neurodegeneration

2018 Seed Grant
David Schoppik, Ph.D.
New York School of Medicine

Neurodegenerative disorders arise as components of the nervous system deteriorate with age. The symptoms accompanying this deterioration become progressively worse, compromising an individual’s ability to function. The progressive and widespread nature of neurodegenerative diseases pose particular challenges to understanding the mechanisms responsible. While considerable progress has been made at the molecular level, how these biochemical events lead to clinical symptoms remains poorly understood. Here we propose to develop a powerful new model system to study progressive neurodegeneration. We will induce neurodegeneration and use cutting-edge non-invasive imaging technology to make longitudinal measurements of brain function. Simultaneously we will monitor emergent symptoms with quantitative measures of behavior. Our aim is to reveal mechanisms of progressive dysfunction and build a framework to one day evaluate therapeutic approaches.

Other Grants

Andre Berndt, Ph.D.
Monitoring Communication in Neuronal Networks in Real Time and at Single Cell Resolution
Visualizing the flow of information through the complex and intertwined networks of the brain is a long‐sought goal of neuroscience. Genetically encoded proteins such as the fluorescent calcium sensor GCaMP…
Denise Cai, Ph.D.
Investigating the Role of Negative Valence in the Temporal Dynamics of Memory-Linking
Determining how distinct memories are formed, linked, and retrieved, and the role of fear in these processes, is an essential part of understanding PTSD, a debilitating disorder characterized by the…
Dr. Weizhe Hong, Ph.D.
Dissecting the Organization and Function of Social Behavioral Circuits in the Amygdala
Social interactions play a crucial role in the reproduction, survival, and physical and mental health of many vertebrate species including humans. Impairment in social behavior is a hallmark of several…
Takashi Kitamura, Ph.D.
Neural Circuit Mechanisms of Behavior-Dependent Representation for Space and Time
The central question in my proposal is whether our perception of time and space share the same circuit mechanisms during our daily life. Recent studies suggest that neurons in the…