A Novel Whole-brain Method for In Vivo Imaging of Progressive Neurodegeneration

2018 Seed Grant
David Schoppik, Ph.D.
New York School of Medicine

Neurodegenerative disorders arise as components of the nervous system deteriorate with age. The symptoms accompanying this deterioration become progressively worse, compromising an individual’s ability to function. The progressive and widespread nature of neurodegenerative diseases pose particular challenges to understanding the mechanisms responsible. While considerable progress has been made at the molecular level, how these biochemical events lead to clinical symptoms remains poorly understood. Here we propose to develop a powerful new model system to study progressive neurodegeneration. We will induce neurodegeneration and use cutting-edge non-invasive imaging technology to make longitudinal measurements of brain function. Simultaneously we will monitor emergent symptoms with quantitative measures of behavior. Our aim is to reveal mechanisms of progressive dysfunction and build a framework to one day evaluate therapeutic approaches.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the Nervous System Constructs Internal Models of the External World
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…