Brain Development: Understanding Neuron Migration

The cortex of the brain has a specific arrangement of specific types of neurons that is essential for its advanced functions. The first cells of cortex produced in the embryo, the Cajal-Retzius cells, migrate on the surface of the brain and from there orchestrate the positioning of the rest of the cortical neurons. We have identified a gene expressed by Cajal-Retzius cells and hypothesize that it is essential for their migration and function, and hence for proper formation of the cortex. We have generated mice lacking this gene and will examine them to test these and other hypotheses.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the Nervous System Constructs Internal Models of the External World
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…