Brain Development: Understanding Neuron Migration

The cortex of the brain has a specific arrangement of specific types of neurons that is essential for its advanced functions. The first cells of cortex produced in the embryo, the Cajal-Retzius cells, migrate on the surface of the brain and from there orchestrate the positioning of the rest of the cortical neurons. We have identified a gene expressed by Cajal-Retzius cells and hypothesize that it is essential for their migration and function, and hence for proper formation of the cortex. We have generated mice lacking this gene and will examine them to test these and other hypotheses.

Other Grants

Andre Berndt, Ph.D.
Monitoring Communication in Neuronal Networks in Real Time and at Single Cell Resolution
Visualizing the flow of information through the complex and intertwined networks of the brain is a long‐sought goal of neuroscience. Genetically encoded proteins such as the fluorescent calcium sensor GCaMP…
Denise Cai, Ph.D.
Investigating the Role of Negative Valence in the Temporal Dynamics of Memory-Linking
Determining how distinct memories are formed, linked, and retrieved, and the role of fear in these processes, is an essential part of understanding PTSD, a debilitating disorder characterized by the…
Dr. Weizhe Hong, Ph.D.
Dissecting the Organization and Function of Social Behavioral Circuits in the Amygdala
Social interactions play a crucial role in the reproduction, survival, and physical and mental health of many vertebrate species including humans. Impairment in social behavior is a hallmark of several…
Takashi Kitamura, Ph.D.
Neural Circuit Mechanisms of Behavior-Dependent Representation for Space and Time
The central question in my proposal is whether our perception of time and space share the same circuit mechanisms during our daily life. Recent studies suggest that neurons in the…