Chemogenetic dissection of sex-specific fear circuits

2016 Seed Grant
Rebecca M. Shansky, Ph.D.
Northeastern University

Although a majority of the population will experience a severe trauma at some point in their lifetime, only about 10% of those people will go on to develop PTSD, which suggests that there are discrete neurobiological factors that confer susceptibility or resilience. Because PTSD is more prevalent in women, identifying sex-specific mechanisms of fear and emotion regulation is critical to the development of more personalized disease prevention and treatment. We recently discovered that a subset of female rats display an active fear response that is not observed in males. A better understanding of the neural circuits that mediate this novel behavior could lead to insight into what makes women susceptible to or resilient against PTSD. This seed project will begin to define the role of prefrontal cortex circuits in fear response strategies, and lay groundwork for future investigations into the cellular and molecular mechanisms that mediate the switch between active and passive fear responses.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…