Cortex Plasticity: How the Brain Interprets Stimuli

The way in which the brain interprets incoming information is constantly changing according to the relevance of the incoming stimuli at that moment in time. This ‘plasticity’ results in part, from changes in the strengths of synaptic signals between neurons. Acetylcholine is a brain chemical that modulates the strength of synapses, but the manner in which it performs this modulation is unclear. In this proposal we will use electrical recording and high-resolution microscopy techniques to measure synaptic function before, during and after release of acetylcholine with ‘optogenetic’ tools. In this way we will determine the sites of action of acetylcholine and the mechanisms by which it alters synaptic signaling between neurons.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…