Cortical and Subcortical Interactions Mediating Value-Based Sensory Processing

2025 Seed Grant
Scott R. Pluta, Ph.D.
Purdue University

Rosalie A. Ciardullo Seed Grant

This project investigates how different parts of the brain work together to positively reinforce our attention while ignoring distractions or negative associations. In this proposal, we will study connections between the cerebral cortex and downstream brain structures to understand the contribution of different neural pathways to this process. We expect our findings to reveal the contribution of specific circuits to value-based decision-making. This research is directly relevant to understanding the neural mechanisms of attention deficits and compulsivity. Ultimately, results from this proposal could facilitate novel treatments for cognitive impairments caused by problematic or uncontrollable sensory associations.

Other Grants

José Manuel Baizabal Carballo, Ph.D., Indiana University Bloomington
Heterochromatin Mechanisms of Cortical Expansion
Neurodevelopmental disorders, such as autism and schizophrenia, are frequently associated with mutations in genes that encode chromatin-modifying enzymes. A subset of these mutations is thought to disrupt compacted chromatin (heterochromatin),…
Jessica L. Bolton, Ph.D., Georgia State University
Chemogenetic Tools in Microglia as a Novel Therapeutic Approach for Brain Disorders
All humans are born with a unique combination of genes, which contribute greatly to who we are. However, early-life experiences such as trauma or hardship, particularly during the first few…
Junyue Cao, Ph.D., The Rockefeller University
Elucidate the Molecular and Cellular Targets of Caloric Restriction in Rejuvenating Aged Mammalian Brain
As we age, the brain’s ability to function declines, increasing the risk of cognitive impairments and neurological diseases like Alzheimer’s and Parkinson’s. Our research investigates how caloric restriction (CR), a…
Vasileios Christopoulos, Ph.D., University of Southern California
Understanding the Mechanisms of Micturition in the Brain and Spinal Cord
This research aims to better understand how the brain and spinal cord work together to control urination, a process known as micturition. In healthy individuals, this process is carefully coordinated…