Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy

2023 Seed Grant
William J. Giardino, Ph.D.
Stanford University

This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed nucleus of the stria terminalis (BNST). Dr. Giardino’s proposal pursues the possibility that these BNST neuropeptide neurons play a role in regulating sudden episodes of muscle weakness and transitions into sleep that interrupt normal wakefulness, called cataplexy. Cataplexy is triggered by powerful emotional stimuli and occurs in many subjects with narcolepsy, a sleep disorder that affects around 1 in 2,000 people. Dr. Giardino’s lab will use advanced techniques to study how these neurons work in a mouse model of narcolepsy, which will help them discover the underlying causes of cataplexy and lead to the development of new treatments for this devastating condition. By gaining insight into how emotional neural systems like BNST neuropeptide neurons control sleep and wakefulness, this research will ultimately improve the quality of life for people with narcolepsy, other sleep disorders, and related mental health conditions.

Other Grants

José Manuel Baizabal Carballo, Ph.D., Indiana University Bloomington
Heterochromatin Mechanisms of Cortical Expansion
Neurodevelopmental disorders, such as autism and schizophrenia, are frequently associated with mutations in genes that encode chromatin-modifying enzymes. A subset of these mutations is thought to disrupt compacted chromatin (heterochromatin),…
Jessica L. Bolton, Ph.D., Georgia State University
Chemogenetic Tools in Microglia as a Novel Therapeutic Approach for Brain Disorders
All humans are born with a unique combination of genes, which contribute greatly to who we are. However, early-life experiences such as trauma or hardship, particularly during the first few…
Junyue Cao, Ph.D., The Rockefeller University
Elucidate the Molecular and Cellular Targets of Caloric Restriction in Rejuvenating Aged Mammalian Brain
As we age, the brain’s ability to function declines, increasing the risk of cognitive impairments and neurological diseases like Alzheimer’s and Parkinson’s. Our research investigates how caloric restriction (CR), a…
Vasileios Christopoulos, Ph.D., University of Southern California
Understanding the Mechanisms of Micturition in the Brain and Spinal Cord
This research aims to better understand how the brain and spinal cord work together to control urination, a process known as micturition. In healthy individuals, this process is carefully coordinated…