Decoding the Molecular Regulators of Synaptic Integrity

2016 Seed Grant
Melanie A. Samuel, Ph.D.
Baylor College of Medicine

This study addresses a critical biological and biomedical problem, molecular control of synaptic reprogramming. Our goals are to dissect the pathways that control how neurons alter connections with synaptic partners using new technical strategies to see and analyze single synapses as they restructure. Results from this study will identify new basic mechanisms that regulate adult synaptic integrity and define molecular targets for repairing nervous system injury.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…