Endoplasmic reticulum structure and function in neuronal maintenance

2015 Seed Grant
Anjon Audhya, Ph.D.
University of Wisconsin – Madison

Our overall goal is to define new mechanisms that sustain and enhance neuron viability and function during development and aging. The functional characterization of TFG, which has been implicated in several axonopathies including hereditary spastic paraplegia, Charot-Marie-Tooth Disease, and proximal dominant hereditary motor and sensory neuropathy, will contribute both to our understanding of the pathomechanisms underlying these diseases and reveal general requirements for lifelong axonal maintenance. Collectively, our studies may uncover new, unifying mechanisms that underlie a variety of neurodegenerative disorders, and establish a stemcell based model system, which is both facile and tractable, and can ultimately gauge the value of therapeutic treatments that are currently under development.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…