Endoplasmic reticulum structure and function in neuronal maintenance

2015 Seed Grant
Anjon Audhya, Ph.D.
University of Wisconsin – Madison

Our overall goal is to define new mechanisms that sustain and enhance neuron viability and function during development and aging. The functional characterization of TFG, which has been implicated in several axonopathies including hereditary spastic paraplegia, Charot-Marie-Tooth Disease, and proximal dominant hereditary motor and sensory neuropathy, will contribute both to our understanding of the pathomechanisms underlying these diseases and reveal general requirements for lifelong axonal maintenance. Collectively, our studies may uncover new, unifying mechanisms that underlie a variety of neurodegenerative disorders, and establish a stemcell based model system, which is both facile and tractable, and can ultimately gauge the value of therapeutic treatments that are currently under development.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…