Nervous System Development by Jaime Garcia-Anoveros

Insm1 in Terminal Neurogenic Proliferation
2009 Seed Grant
Jaime Garcia-Anoveros, Ph.D.
Northwestern University

The size and shape of every part of the brain are determined by how much the neuronal progenitor cells divide during embryogenesis. In nematodes, we identified a gene that is expressed at the end of neuronal proliferation and delimits the number of neurons produced. In mammals, we identified a homologous gene that is similarly expressed at the end of neuronal proliferation. We have mutated this gene in mice and will determine whether it regulates neuronal proliferation and brain size.

Other Grants

Rebekah C. Evans, Ph.D., Georgetown University
In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise
Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it…
William J. Giardino, Ph.D. Stanford University
Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy
This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed…
Howard Gritton, Ph.D., University of Illinois
Attention Mechanisms Contributing to Auditory Spatial Processing.
Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded…
Nora Kory, Ph.D., Harvard University
Elucidating the Fates and Functions of Lactate in the Brain
The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a…