Neural Circuit Mechanisms in the Early Stage of Alzheimer’s Disease

2017 Seed Grant
Kei Igarashi, Ph.D.
University of California, Irvine

In Alzheimer’s disease, even a small improvement in a patient’s memory may provide them with a vast improvement in their quality of life. ln my previous studies, I discovered that neurons from two separate regions of the rat brain develop a synchronized electrical signal that may help increase long-term memory formation during learning (lgarashi et al., Nature 2014). This project will test if this synchronized brain activity is affected in an Alzheimer’s disease mouse model, and explore the possibility that healthy neuronal activity can be restored, leading to the promise of improving learning and performance in people suffering from Alzheimer’s and other memory impairments.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…