Neural Circuit Mechanisms in the Early Stage of Alzheimer’s Disease

2017 Seed Grant
Kei Igarashi, Ph.D.
University of California, Irvine

In Alzheimer’s disease, even a small improvement in a patient’s memory may provide them with a vast improvement in their quality of life. ln my previous studies, I discovered that neurons from two separate regions of the rat brain develop a synchronized electrical signal that may help increase long-term memory formation during learning (lgarashi et al., Nature 2014). This project will test if this synchronized brain activity is affected in an Alzheimer’s disease mouse model, and explore the possibility that healthy neuronal activity can be restored, leading to the promise of improving learning and performance in people suffering from Alzheimer’s and other memory impairments.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…