Neuron Development

Neural stem and progenitor cells generate the massive diversity of neurons and glia that comprise the nervous system. Understanding the regulation of how neural progenitors divide and differentiate will provide important insight into disease mechanisms and enable the development of new therapeutic approaches. Our previous studies in the developing cerebral cortex suggest that stem and progenitor cells can support the growth and differentiation of other stem and progenitor cells. The goals of this proposal are to examine whether similar support mechanisms exist in the adult brain, and to elucidate the mechanisms by which cell adhesion may regulate the adult neural stem cell microenvironment. We will use mouse models of brain development for these studies.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The role of microglial lysosomes in selective neuronal vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the nervous system constructs internal models of the external world
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the orchestra of movement—functional role of striatal astrocytes in health and disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…