Odor Perception

This proposal is for exploring the ways in which odor mixtures are perceived. Many mixtures have synthetic or configural qualities, meaning that the mixture smells different from its components. Other mixtures have elemental qualities, meaning that the mixture smells like the sum of the components. Recent advances in understanding the structure of odor receptors in the nose and in their patterns of connection into the first stage of processing in the brain (olfactory bulb) have given rise to a theory of odor mixture perception based on overlap at receptors or in their input patterns. This theory proposes that mixtures of odors that overlap in their input representation have more configural perceptual qualities and that those that do not overlap have more elemental properties. This addresses issues that are at the core of understanding the nature of odor perception as it arises from the anatomy of the olfactory receptors and the first stages of odor processing in the brain. Our previous work has both supported and cast doubt on this theory. We plan a thorough test of the theory using a behavioral method that we have recently developed in the laboratory. We will use rats because their olfactory anatomy is very similar to the human system, and they offer the advantage of numerous studies describing specific receptor binding properties and input patterns. We will test the theory in three ways, addressing 1) the ways in which molecules bind to the same or different olfactory receptors, 2) the amount of overlap in the olfactory bulb and 3) the robustness of these results by also testing odors that are found in body fluids of many mammals.
Olfactory deficits are common in disorders that affect cognitive function, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, schizophrenia and depression. In some cases, these deficits are among the first signs of the onset of these disorders or are predictive in development of the disorder years in the future. In addition, temporal lobe epilepsy, one of the most common forms of seizure disorder, has been shown experimentally to engage and in some cases rely on olfactory circuitry. Despite the relative importance of this system in human cognitive structures, relatively little is known about the mechanisms involved or the structure of odor space in which the system operates. This impairs researchers’ ability to evaluate the specific nature of the deficits seen in many disorders. In olfaction we have little knowledge of what features constitute the fundamental properties of odors. Most natural odors are complex mixtures, and only a handful of studies have approached the issue of mixture perception in a systematic or theoretically driven fashion. Having data for specific combinations of chemicals and examination of the underlying neural processes that contribute to odor mixture perception will help in understanding the neural processes involved in the early stages of disorders such as Alzheimer’s and Parkinson’s diseases. These data will also aid in development of more specific clinical olfactory tests.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…