Parkinson’s Disease

Parkinson’s disease (PD) afflicts approximately 1.5 million Americans annually.  Although drugs such as levodopa (Sinemet) are available for the treatment of parkinsonian symptoms, they often produce disabling side effects called dyskinesias.  These side effects are thought to arise as a result of abnormal drug- and disease-induced neurotransmitter interactions in an area of the brain called the basal ganglia.  Our proposed studies will use an animal model of PD and examine the utility of combining a new drug (a cyclic nucleotide phosphodiesterase inhibitor called TP-10) with levodopa for treating disease symptoms and associated side effects.   We will also assess how this novel drug combination affects neuron activity in the basal ganglia.  We anticipate that our proposed studies will identify more efficacious treatment strategies for patients suffering from PD and levodopa-induced dyskinesias.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…