Parkinson’s Disease

Parkinson’s disease (PD) afflicts approximately 1.5 million Americans annually.  Although drugs such as levodopa (Sinemet) are available for the treatment of parkinsonian symptoms, they often produce disabling side effects called dyskinesias.  These side effects are thought to arise as a result of abnormal drug- and disease-induced neurotransmitter interactions in an area of the brain called the basal ganglia.  Our proposed studies will use an animal model of PD and examine the utility of combining a new drug (a cyclic nucleotide phosphodiesterase inhibitor called TP-10) with levodopa for treating disease symptoms and associated side effects.   We will also assess how this novel drug combination affects neuron activity in the basal ganglia.  We anticipate that our proposed studies will identify more efficacious treatment strategies for patients suffering from PD and levodopa-induced dyskinesias.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
How the Nervous System Constructs Internal Models of the External World
As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…